Substance addictions and suicidal thoughts and behaviors: Evidence from a multi-wave epidemiological study.

Substance addiction (SA) is a risk factor of suicidal thoughts and behaviors (STB), although it is still unclear which SAs are reliably associated with increased risk for suicidal ideation, planning, and attempt. The current study aimed to meet this goal using data from the National Survey on Drug Use and Health (NSDUH) referring to years from 2008 to 2020. The information extracted included sociodemographic and contextual information, eleven SAs (e.g., nicotine, alcohol, marijuana, cocaine, pain relievers, heroin, inhalants, hallucinogens, sedatives, stimulants, and tranquillizers), and STB. The analysis revealed that SAs for alcohol, pain relievers, marijuana, and cocaine were stable and reliable predictors for STB (e.g., suicidal ideation, planning, and attempt), while cocaine was not a stable predictor for suicide attempt. The selected SAs model showed a greater predictive accuracy than only sociodemographic and contextual factors as well as not selected SAs. Moreover, selected SAs showed comparable predictive accuracy to the full model. Furthermore, SA to alcohol showed to be an extremely effective predictor of STB, having a comparable predictive accuracy to all the other ten SAs together. In conclusion, SAs to pain relievers, alcohol, marijuana, and cocaine can be considered as important risk factors for concurrent STB.

Body Uneasiness, Body Figure Perception, and Body Weight: Factor Structure and Longitudinal Measurement Invariance of a Set of Attitudinal and Perceptual Body Image Assessment Tools in Adolescents.

Body image is a multifaceted construct that includes attitudinal and perceptual components, but its attention has mainly been focused on the facet of body dissatisfaction. The present longitudinal study extended the validation of a multifacet attitudinal questionnaire, the Body Uneasiness Test (BUT), against perceptions of body shape and weight. A convenient sample of adolescents took part in a 2-year unbalanced panel study (5 waves). The participants completed the BUT questionnaire and selected their perceived actual, ideal, and reflected body figures along the Contour Drawing Rating Scale; ideal/actual and ideal/normative body mass index discrepancies were also included. After replicating the expected five-factor structure of the BUT items, results from confirmatory factor analysis revealed that the five BUT scales loaded on an attitudinal dimension, whereas the perceived body figures and the discrepancy indices were on a perceptive domain. Such a two-domain structure of body image measures showed gender and seasonal (1-year) measurement invariance, whereas longitudinal 6-month and 18-month invariance partially failed. Overall, the present findings support the validity of the Body Uneasiness Test in adolescence, further demonstrating a preliminary multidimensional structure of body image onto which attitudinal and perceptual body image-related measures were projected.

Defense styles, well-being, and functional disability in the African context: A structured interview-based study.

OBJECTIVE: We investigated the defense styles in the African context by exploring their internal structure in Burkinabé individuals. Moreover, we explored how defense styles were related to sociocultural variables. Finally, we tested whether defense styles could mediate the relationship between sociocultural variables and mental well-being as well as functional disability. METHOD: The study recruited 998 individuals (66.9% male; age = 25.50 ± 7.8 years) living in Burkina Faso. Standard measures for defense mechanisms, mental well-being, and functional disability were administered as a structured interview in the local vehicular language, that is, Dyula. RESULTS: Principal component analysis identified three major defense styles-mature, neurotic, and immature. Gender, formal education, living area, and believing in traditional practices were associated with any of the three defense styles. Moreover, the immature style mediated the impact of sociocultural variables on specific outcomes, such as higher functional disability and lower mental well-being. The neurotic style was associated with lower functional disability, while the mature style was not associated with any of the outcome variables. CONCLUSION: Our study provided preliminary support to the notion that defense styles may function similarly across cultures and they are likely reactive to the sociocultural context.

Angry and happy expressions affect forward gait initiation only when task relevant.

Whole-body movements represent an ecologically valid model for assessing the effect of emotional stimuli valence on approach/avoidance reactions as they entail a change of the physical distance between such stimuli and the self. However, research in this field has provided inconsistent results as the task relevance of the emotional content of the stimuli was not properly controlled, and very often, it is impossible to dissociate the effect of arousal from that of valence. To overcome these limitations, we studied the effect of facial emotional expressions (anger and happiness) on forward gait initiation using an experimental paradigm that allows us to compare the impact of the stimuli emotional content when they are task relevant and when they are not. We found that angry and happy expressions altered forward gait initiation parameters differently only when relevant for ongoing goals. In particular, both the reaction times and the percentages of omission errors increased when the go signal was an angry face compared to when the go signal was a happy face. These results indicate that forward step movements share the same features as reaching arm movements regarding emotional stimuli, that is, facial emotions do not automatically influence behavioral responses. Instead, their effects depend critically on their conscious appraisal. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Fostering emotional intelligence in preadolescence: Effects of a pilot training on emotions, coping and psychological well-being.

The purpose of the present study was to examine the efficacy of a short training programme (eight 1-hour sessions) aimed to promote Emotional Intelligence (EI) abilities in primary school on a set of outcomes related to affect, coping and psychological well-being. Sixty-eight preadolescents (10.68±.58 years) were randomly assigned to either the experimental condition (EI training) or the active control condition (pro-environmental training). ANOVAs and Bayesian analyses were performed on pre/post-training measures of ability and trait EI, positive/negative affect, regulatory emotional self-efficacy, coping styles, and psychological well-being. Results showed that only in the EI training condition emotional abilities significantly improved, whereas negative affect and the preference for distraction coping significantly diminished. Although the effects of the present EI training did not extend to the other measures, the findings suggest its effectiveness in improving preadolescents' EI basic skills and some important adjustment variables. This study confirms the efficacy of short school-based programmes in enhancing EI abilities and highlights the importance of further investigating the training features required to extend its benefits also to psychological well-being. Implications for research and educational practices are discussed.

Perception of biological motion. No sensitivity differences between patients with Parkinson's disease and healthy observers.

The use of biological motion (BM) stimuli (point-light walkers PLW) may be a novel alternative to improve the clinical impact of Action Observation treatments in Parkinson's Disease, by directing the patient's attentional focus on gait kinematics. However, the recognition of biological motion in Parkinson's patients has thus far been controversial. To evaluate the clinical feasibility of using BM stimuli in Action Observation treatments, we aimed at investigating whether Parkinson's patients in the ON-state condition can identify and use gender-specific cues conveyed by the body structure and by the kinematics of gait of a PLW. 30 Parkinson's patients and 30 healthy elderly observers were tested in a gender identification task with PLW. Parkinson's patients were able to correctly identify the gender of PLW; no differences were found between the two groups of observers. While for both groups, the gender identification task was easier when it required a judgment on a healthy PLW. Lastly, we found that females were more sensitive than males in our identification task. Our study shows that Parkinson's patients in the ON-state condition are able to extract subtle structural and kinematic characteristics from biological motion stimuli, which is favorable to the use of BM in Action Observation treatments.

Individual differences in habituation: Innate covariation between habituation, exploration, and body size in naïve chicks (Gallus gallus).

Habituation to novel stimuli has been associated with behavioural differences among individuals in numerous animal species. Because the habituation mechanisms depend on previous experiences with a stimulus, one would expect individuals to develop their habituation capacity based on the life experiences that also shape their behavioural traits. And indeed, in adult lizards, exploratory behaviour and body size correlates with habituation. However, here we show that the same factors correlate with habituation of domestic chicks reared under controlled laboratory conditions and tested in the first 3 days after hatching. This result indicates that the covariation between habituation, exploration, and body size does not necessarily depend on experience. Rather, it represents an innate association between exploratory behaviour and risk assessment, which may provide an immediate survival advantage to new-borns of this precocial avian species.

A complete season with attendance restrictions confirms the relevant contribution of spectators to home advantage and referee bias in association football.

Background: Due to the unfortunate pandemic situation, the phenomena of home advantage and referee bias in sports have recently received a particular research attention, especially in association football. In this regard, several studies were conducted on the last portion of the 2019-20 season: the majority of them suggests a reduction-but not the elimination-of the two phenomena, with some exceptions in which no reduction was found or, at the other extreme, the phenomena were not observed at all. Methods: The continuation of the pandemic made it possible to replicate the previous studies considering the complete 2020-21 season, thus with the important added value of having a fully balanced home/away schedule-and a higher number of matches-in the various leagues. In particular, the sample of the present study consisted of 3,898 matches from the first and second divisions of the UEFA top five ranked countries, that is, England, Spain, Italy, Germany, and France. For the home advantage, the following variables were examined: distribution of matches outcomes and home advantage for points (also for previous seasons from the 2014-15 one); ball possession; total shots; shots on goal; and corner kicks. Instead, for he referee bias, the following variables were examined: fouls; yellow cards; red cards; penalty kicks; and extra time. Chi-square tests were used to compare the distribution of matches outcomes, and t-tests to compare home vs. away data for the other variables in the 2020-21 season; Bayesian and equivalence analyses were also conducted. Results: The main results are as follows: (a) the distribution of matches outcomes in the 2020-21 season was significantly different from that of the last five complete seasons with spectators (Chi-square = 37.42, df = 2, p < 0.001), with fewer home victories and more away victories; the resulting values of the home advantage for points were 54.95% for the 2020-21 season, and 59.36% for the previous seasons; (b) for the other home advantage variables, a statistically significant overall advantage for the home team emerged; nevertheless, the strength of the differences between home and away teams was generally small (0.09 < Cohen's d < 0.17), and the corresponding means can be considered statistically equivalent for all variables but the total shots; (c) no statistically significant differences emerged between home and away teams for any of the referee bias variables. Discussion: These findings demonstrate that the absence of spectators significantly reduced the home advantage compared to previous seasons with spectators. A slight home advantage persisted in the 2020-21 season, probably due to other factors, namely, learning and travel, according to the model by Courneya & Carron (1992). Conversely, the referee bias was not observed, suggesting that it mainly derives from the pressure normally exerted by spectators.

Psychological well-being in childhood: The role of trait emotional intelligence, regulatory emotional self-efficacy, coping and general intelligence.

Given the increase of mental health problems in youth, focusing on the promotion of psychological well-being is essential. Among the variables recognized as linked to children's psychological well-being, trait emotional intelligence, emotional self-efficacy and coping seem to be crucial, whereas the role played by intelligence is still controversial. In the present study, we explored the combined effects of these variables, aimed at disentangling their unique contribution to psychological well-being of 74 children (41 males, mean age: 9.03 years). We administered verbal and reasoning tests as intelligence measures and self-report questionnaires to assess trait emotional intelligence, regulatory emotional self-efficacy, coping styles, psychological well-being. Correlations revealed two independent clusters of variables: a first cluster including intelligence indexes and a second cluster including psychological well-being, trait emotional intelligence, regulatory emotional self-efficacy and adaptive coping styles. Hierarchical regression analyses showed that only trait emotional intelligence and positive restructuring coping style significantly contributed to psychological well-being. This study highlights that, unlike general intelligence, trait emotional intelligence was associated to psychological well-being, whereas coping styles play a negligible role in explaining this relationship. These findings are valuable in identifying the most relevant factors for children's adjustment and in enhancing emotion-related aspects in interventions for psychological well-being promotion.

Extracellular Vesicles Secreted by Mesenchymal Stromal Cells Exert Opposite Effects to Their Cells of Origin in Murine Sodium Dextran Sulfate-Induced Colitis.

Several reports have described a beneficial effect of Mesenchymal Stromal Cells (MSCs) and of their secreted extracellular vesicles (EVs) in mice with experimental colitis. However, the effects of the two treatments have not been thoroughly compared in this model. Here, we compared the effects of MSCs and of MSC-EV administration in mice with colitis induced by dextran sulfate sodium (DSS). Since cytokine conditioning was reported to enhance the immune modulatory activity of MSCs, the cells were kept either under standard culture conditions (naïve, nMSCs) or primed with a cocktail of pro-inflammatory cytokines, including IL1ß, IL6 and TNFα (induced, iMSCs). In our experimental conditions, nMSCs and iMSCs administration resulted in both clinical and histological worsening and was associated with pro-inflammatory polarization of intestinal macrophages. However, mice treated with iEVs showed clinico-pathological improvement, decreased intestinal fibrosis and angiogenesis and a striking increase in intestinal expression of Mucin 5ac, suggesting improved epithelial function. Moreover, treatment with iEVs resulted in the polarization of intestinal macrophages towards and anti-inflammatory phenotype and in an increased Treg/Teff ratio at the level of the intestinal lymph node. Collectively, these data confirm that MSCs can behave either as anti- or as pro-inflammatory agents depending on the host environment. In contrast, EVs showed a beneficial effect, suggesting a more predictable behavior, a safer therapeutic profile and a higher therapeutic efficacy with respect to their cells of origin.

Psychometric Properties of the Syrian Arabic Version of the Impact of Event Scale-Revised in the Context of the Syrian Refugee Crisis.

The Impact of Event Scale-Revised (IES-R) is a widely used self-report questionnaire used to assess symptoms of posttraumatic stress disorder (PTSD). Although the IES-R has been translated and validated in multiple languages, no previous version has employed the Arabic dialect commonly spoken in Syria. The present work aimed to assess the psychometric properties of a Syrian Arabic version of the IES-R. Syrian citizens (N = 288) living in refugee camps in Turkey were administered the Syrian Arabic IES-R as part of a humanitarian aid project focused on providing psychological assistance. The data were analyzed with respect to 10 previously published factor solutions. We found that the best-fitting model was a four-factor structure that included factors involving Avoidance-Numbing, Intrusion, Hyperarousal, and Sleep Disturbance. The model showed strong measurement invariance between male and female subsamples, allowing for meaningful comparisons of the factor means. Overall, the present findings support the validity of a new version of the IES-R, which can be used by both researchers and clinicians responding to the urgent need for psychological care for Syrian refugees fleeing war-related violence.

Muscle functional recovery is driven by extracellular vesicles combined with muscle extracellular matrix in a volumetric muscle loss murine model.

Biological scaffolds derived from decellularized tissues are being investigated as a promising approach to repair volumetric muscle losses (VML). Indeed, extracellular matrix (ECM) from decellularized tissues is highly biocompatible and mimics the original tissue. However, the development of fibrosis and the muscle stiffness still represents a major problem. Intercellular signals mediating tissue repair are conveyed via extracellular vesicles (EVs), biologically active nanoparticles secreted by the cells. This work aimed at using muscle ECM and human EVs derived from Wharton Jelly mesenchymal stromal cells (MSC EVs) to boost tissue regeneration in a VML murine model. Mice transplanted with muscle ECM and treated with PBS or MSC EVs were analyzed after 7 and 30 days. Flow cytometry, tissue analysis, qRT-PCR and physiology test were performed. We demonstrated that angiogenesis and myogenesis were enhanced while fibrosis was reduced after EV treatment. Moreover, the inflammation was directed toward tissue repair. M2-like, pro-regenerative macrophages were significantly increased in the MSC EVs treated group compared to control. Strikingly, the histological improvements were associated with enhanced functional recovery. These results suggest that human MSC EVs can be a naturally-derived boost able to ameliorate the efficacy of tissue-specific ECM in muscle regeneration up to the restored tissue function.

The influence of encoding and testing directions on retrieval of spatial information in explored and described environments.

The verbal descriptions of an environment elicit a spatial mental model, in which the linear disposition of the described objects might be related to the properties of the description. In particular the direction from which the environment is encoded might shape the spatial mental model, as a consequence of a cultural bias in reading and writing direction. The aim of the present study was to examine the influence of the direction in which objects are encoded on the retrieval of spatial information. In two experiments we asked participants to encode an environment through either physical exploration or verbal description, that are encoding modalities which preserve the sequential presentation of spatial information. We manipulated both the encoding and testing directions of the spatial information, and tested participants by using a two-alternative forced choice task. In both experiments, the results did not reveal any significant effect, disconfirming the idea of the left-right cultural bias for western people for this type of task. The lack of effect suggests that encoding an environment through physical movement and verbal descriptions determines the development of a mental representation which is relatively independent from encoding sequential order.

The sound of silence in association football: Home advantage and referee bias decrease in matches played without spectators.

The home advantage and unconscious referee bias are two well-documented phenomena in professional sports, especially in association football. Among the various factors determining them, the crowd noise is considered as one of the most relevant; yet, the majority of previous studies could not isolate its contribution. The possibility to study the effects of crowd noise - or, better, of its absence - in an ecological context was given by the matches played behind closed doors due to the COVID-19 pandemic. The aim of the present study was to investigate whether home advantage and referee bias still occur (and to what extent) during matches played in absence of spectators. In particular, the focus was on the first and second divisions of the top four countries in the UEFA ranking, for a total of 841 matches behind closed doors. The hypothesis was that, if these phenomena are largely due to the effect of crowd noise, the absence of spectators should reduce their occurrence. Various parameters for each of the two phenomena were considered, and the analyses revealed a reduction of home advantage and the absence of referee bias. The results bring further support to the claim that, among all the factors contributing to home advantage and referee bias, crowd noise has a relevant role. Thus, spectators can significantly contribute to determine the dynamics and the outcomes of professional football matches.

Action observation improves sit-to-walk in patients with Parkinson's disease and freezing of gait. Biomechanical analysis of performance.

INTRODUCTION: Freezing of gait (FoG) is one of the most disabling gait disorders in Parkinson's disease (PD), reflecting motor and cognitive impairments, mainly related to dopamine deficiency. Recent studies investigating kinematic and kinetic factors affecting gait in these patients showed a postural instability characterized by disturbed weight-shifting, inappropriate anticipatory postural adjustment, worse reactive postural control, and a difficulty executing complex motor tasks (i.e. sit-to-walk). These symptoms are difficult to alleviate and not very responsive to Levodopa. For this reason, additional therapeutic actions based on specific therapeutic protocols may help patients with their daily lives. We conducted a randomized control trial aimed to test if two clinical protocols for PD patients with FoG were effective to improve postural control. METHODS: Rehabilitation protocols, conceived to improve gait, were based on learning motor exercises with the Action Observation plus Sonification (AOS) technique, or by the use of external sensory cues. We collected biomechanical data (Center of Mass COM, Center of Pressure COP, and moving timings), using the sit-to-walk task as a measure of motor and gait performance. RESULTS: Kinetic and kinematic data showed that when treatment effects consolidate, patients treated with AOS protocol are more efficient in merging subsequent motor tasks (sit-to-stand and gait initiation), and diminished the total moving time and the area of the COP positions. CONCLUSION: We demonstrated for the first time that PD patients with FoG treated with an AOS protocol aimed at relearning appropriate gait patterns increased balance control and re-acquired more efficient postural control.

Multi-UAV Path Planning for Autonomous Missions in Mixed GNSS Coverage Scenarios.

This paper presents an algorithm for multi-UAV path planning in scenarios with heterogeneous Global Navigation Satellite Systems (GNSS) coverage. In these environments, cooperative strategies can be effectively exploited when flying in GNSS-challenging conditions, e.g., natural/urban canyons, while the different UAVs can fly as independent systems in the absence of navigation issues (i.e., open sky conditions). These different flight environments are taken into account at path planning level, obtaining a distributed multi-UAV system that autonomously reconfigures itself based on mission needs. Path planning, formulated as a vehicle routing problem, aims at defining smooth and flyable polynomial trajectories, whose time of flight is estimated to guarantee coexistence of different UAVs at the same challenging area. The algorithm is tested in a simulation environment directly derived from a real-world 3D scenario, for variable number of UAVs and waypoints. Its solution and computational cost are compared with optimal planning methods. Results show that the computational burden is almost unaffected by the number of UAVs, and it is compatible with near real time implementation even for a relatively large number of waypoints. The provided solution takes full advantage from the available flight resources, reducing mission time for a given set of waypoints and for increasing UAV number.

Imagined Intergroup Physical Contact Improves Attitudes Toward Immigrants.

In this set of research, we investigated the effects of intergroup physical contact on intergroup attitudes by relying on indirect contact strategies, namely the imagined contact paradigm. We implemented the imagined contact paradigm by leading participants to shape the mental imagery upon pictorial information. Specifically, in Study 1 participants saw a picture of a white hand touching a black hand [i.e., intergroup physical contact condition (InterPC)] or a picture of an outdoor scene (i.e., control condition), and were asked to imagine being either the toucher or in the outdoor scene, respectively. Results demonstrated that InterPC compared to control condition reduced intergroup bias. In Study 2 we compared the InterPC condition to a condition in which participants saw a white hand touching another white hand [i.e., intragroup physical contact (IntraPC)], and imagined to be the toucher. Again, we found that participants in the InterPC condition showed reduced intergroup bias compared to the IntraPC. Study 3 replicated results of Studies 1 and 2 by using an implicit measure of prejudice. Also, Study 3 further showed that asking participants to merely look at the picture of a white hand touching a black hand, without imagining being the toucher was not effective in reducing implicit prejudice. Results were discussed with respect to the literature on physical contact and prejudice reduction processes.

Postural control deficit during sit-to-walk in patients with Parkinson's disease and freezing of gait.

INTRODUCTION: The intricate linkage between Freezing of Gait (FoG) and postural control in Parkinson's disease (PD) is unclear. We analyzed the impact of FoG on dynamic postural control. METHODS: 24 PD patients, 12 with (PD + FoG), 12 without FoG (PD-FoG), and 12 healthy controls, were assessed in ON state. Mobility and postural control were measured with clinical scales (UPDRS III, BBS, MPAS) and with kinematic and kinetic analysis during three tasks, characterized by levels of increasing difficulty to plan sequential movement of postural control: walk (W), gait initiation (GI) and sit-to-walk (STW). RESULTS: The groups were balanced by age, disease duration, disease severity, mobility and balance. During STW, the spatial distribution of COP trajectories in PD + FoG patients are spread over medial-lateral space more than in the PD-FoG (p < .001). Moreover, the distribution of COP positions. in the transition between sit-to-stand and gait initiation, is not properly shifted toward the leading leg, as in PD-FoG and healthy controls, but it is more centrally dispersed (p < .01) with a delayed weight forward progression (p < .05). In GI task and walk task, COM and COP differences are less evident and even absent between PD patients. CONCLUSION: PD + FoG show postural control differences in STW, compared with PD-FoG and healthy. Different spatial distribution of COP trajectories, between two PD groups are probably due to a deficit to plan postural control during a more demanding motor pattern, such as STW.

Hardware in the Loop Performance Assessment of LIDAR-Based Spacecraft Pose Determination.

In this paper an original, easy to reproduce, semi-analytic calibration approach is developed for hardware-in-the-loop performance assessment of pose determination algorithms processing point cloud data, collected by imaging a non-cooperative target with LIDARs. The laboratory setup includes a scanning LIDAR, a monocular camera, a scaled-replica of a satellite-like target, and a set of calibration tools. The point clouds are processed by uncooperative model-based algorithms to estimate the target relative position and attitude with respect to the LIDAR. Target images, acquired by a monocular camera operated simultaneously with the LIDAR, are processed applying standard solutions to the Perspective-n-Points problem to get high-accuracy pose estimates which can be used as a benchmark to evaluate the accuracy attained by the LIDAR-based techniques. To this aim, a precise knowledge of the extrinsic relative calibration between the camera and the LIDAR is essential, and it is obtained by implementing an original calibration approach which does not need ad-hoc homologous targets (e.g., retro-reflectors) easily recognizable by the two sensors. The pose determination techniques investigated by this work are of interest to space applications involving close-proximity maneuvers between non-cooperative platforms, e.g., on-orbit servicing and active debris removal.

Action Observation Plus Sonification. A Novel Therapeutic Protocol for Parkinson's Patient with Freezing of Gait.

Freezing of gait (FoG) is a disabling symptom associated with falls, with little or no responsiveness to pharmacological treatment. Current protocols used for rehabilitation are based on the use of external sensory cues. However, cued strategies might generate an important dependence on the environment. Teaching motor strategies without cues [i.e., action observation (AO) plus Sonification] could represent an alternative/innovative approach to rehabilitation that matters most on appropriate allocation of attention and lightening cognitive load. We aimed to test the effects of a novel experimental protocol to treat patients with Parkinson's disease (PD) and FoG, using functional, and clinical scales. The experimental protocol was based on AO plus Sonification. 12 patients were treated with 8 motor gestures. They watched eight videos showing an actor performing the same eight gestures, and then tried to repeat each gesture. Each video was composed by images and sounds of the gestures. By means of the Sonification technique, the sounds of gestures were obtained by transforming kinematic data (velocity) recorded during gesture execution, into pitch variations. The same 8 motor gestures were also used in a second group of 10 patients; which were treated with a standard protocol based on a common sensory stimulation method. All patients were tested with functional and clinical scales before, after, at 1 month, and 3 months after the treatment. Data showed that the experimental protocol have positive effects on functional and clinical tests. In comparison with the baseline evaluations, significant performance improvements were seen in the NFOG questionnaire, and the UPDRS (parts II and III). Importantly, all these improvements were consistently observed at the end, 1 month, and 3 months after treatment. No improvement effects were found in the group of patients treated with the standard protocol. These data suggest that a multisensory approach based on AO plus Sonification, with the two stimuli semantically related, could help PD patients with FoG to relearn gait movements, to reduce freezing episodes, and that these effects could be prolonged over time.